Cargando…

Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections

The increasing antibiotic resistance is a clinical problem worldwide. Numerous Gram-negative bacteria have already become resistant to the most widely used class of antibacterial drugs, β-lactams. One of the main mechanisms is inactivation of β-lactam antibiotics by bacterial β-lactamases. Appearanc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grigorenko, Vitaly G., Khrenova, Maria G., Andreeva, Irina P., Rubtsova, Maya Yu., Lev, Anastasia I., Novikova, Tatiana S., Detusheva, Elena V., Fursova, Nadezhda K., Dyatlov, Ivan A., Egorov, Alexey M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837113/ https://www.ncbi.nlm.nih.gov/pubmed/35163756 http://dx.doi.org/10.3390/ijms23031834

Ejemplares similares

The Role of the Ω-Loop in Regulation of the Catalytic Activity of TEM-Type β-Lactamases
por: Egorov, Alexey, et al.
Publicado: (2019)

Mutual influence of secondary and key drug‐resistance mutations on catalytic properties and thermal stability of TEM‐type β‐lactamases
por: Grigorenko, Vitaly, et al.
Publicado: (2017)

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)
por: Abouyannis, Michael, et al.
Publicado: (2022)

Influence of the Active Site Flexibility on the Efficiency of Substrate Activation in the Active Sites of Bi-Zinc Metallo-β-Lactamases
por: Krivitskaya, Alexandra V., et al.
Publicado: (2022)

Boronic Acids as Prospective Inhibitors of Metallo-β-Lactamases: Efficient Chemical Reaction in the Enzymatic Active Site Revealed by Molecular Modeling
por: Krivitskaya, Alexandra V., et al.
Publicado: (2021)

Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase
por: Levina, Elena O., et al.
Publicado: (2020)

Detection of Metallo-Beta Lactamases Among Carbapenem-Resistant Pseudomonas aeruginosa
por: Farajzadeh Sheikh, Ahmad, et al.
Publicado: (2014)

Increasing Carbapenem-Resistant Gram-Negative Bacilli and Decreasing Metallo-β-Lactamase Producers over Eight Years from Korea
por: Lee, Yangsoon, et al.
Publicado: (2015)

ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
por: Samuelsen, Ørjan, et al.
Publicado: (2020)

Drug development concerning metallo-β-lactamases in gram-negative bacteria
por: Li, Xiuyun, et al.
Publicado: (2022)

In vitro Effect of the Combination of Aztreonam and Amoxicillin/Clavulanic Acid Against Carbapenem-Resistant Gram-Negative Organisms Producing Metallo-β-Lactamase
por: Xu, Qian, et al.
Publicado: (2021)

Phenotypic and genotypic detection of metallo-beta-lactamases in Carbapenem resistant Acinetobacter baumannii
por: Moulana, Zahra, et al.
Publicado: (2020)

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.
por: Rossolini, G M, et al.
Publicado: (2000)

New Delhi Metallo-β-Lactamase-1 in Carbapenem-Resistant Salmonella Strain, China
por: Huang, Jinwei, et al.
Publicado: (2013)

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases
por: Lisa, María-Natalia, et al.
Publicado: (2017)

Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study
por: Frolov, Nikita, et al.
Publicado: (2022)

Carbapenem-hydrolyzing metallo-beta-lactamase from a nosocomial isolate of Pseudomonas aeruginosa in France.
por: Poirel, L, et al.
Publicado: (2000)

Endemic Carbapenem-resistant Pseudomonas aeruginosa with Acquired Metallo-β-lactamase Determinants in European Hospital
por: Lagatolla, Cristina, et al.
Publicado: (2004)

Carbapenem-Resistant Pseudomonas aeruginosa–Carrying VIM-2 Metallo-β-Lactamase Determinants, Croatia
por: Sardelic, Sanda, et al.
Publicado: (2003)

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota
por: Gudeta, Dereje D., et al.
Publicado: (2016)

Small Molecule Carboxylates Inhibit Metallo-β-lactamases and Resensitize Carbapenem-Resistant Bacteria to Meropenem
por: Tehrani, Kamaleddin H. M. E., et al.
Publicado: (2020)

Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance
por: Wachino, Jun-ichi, et al.
Publicado: (2020)

Genome Sequences of Two NDM-1 Metallo-β-Lactamase-Producing Multidrug-Resistant Strains of Klebsiella pneumoniae with a High Degree of Similarity, One of Which Contains Prophage
por: Volozhantsev, Nikolay V., et al.
Publicado: (2017)

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
por: Reddy, Nakita, et al.
Publicado: (2023)

New Delhi metallo-β-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya
por: Kraiem, Abdulmajeed G., et al.
Publicado: (2015)

Evaluating the Efficacies of Carbapenem/β-Lactamase Inhibitors Against Carbapenem-Resistant Gram-Negative Bacteria in vitro and in vivo
por: El Hafi, Bassam, et al.
Publicado: (2019)

Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem
por: Tehrani, Kamaleddin Haj Mohammad Ebrahim, et al.
Publicado: (2017)

Prevalence of metallo-β-lactamase acquired genes among carbapenems susceptible and resistant Gram-negative clinical isolates using multiplex PCR, Khartoum hospitals, Khartoum Sudan
por: Adam, Mudathir Abdallah, et al.
Publicado: (2018)

Further Modification of the Modified Hodge Test for Detecting Metallo-β-Lactamase-Producing Carbapenem-Resistant Enterobacteriaceae
por: Kim, Hyun-Ki, et al.
Publicado: (2015)

Usefulness of phenotypic and genotypic methods for metallo-beta-lactamases detection in carbapenem-resistant Acinetobacter baumannii strains
por: Szejbach, Aleksandra, et al.
Publicado: (2013)

Detection of metallo-beta lactamases and oxacillinase genes in carbapenem-resistant Acinetobacter baumannii strains isolated in Morocco
por: Massik, Abdelhamid, et al.
Publicado: (2021)

Screening for Metallo-Beta-Lactamases Using Non-Carbapenem Agents: Effective Detection of MBL-Producing Enterobacterales and Differentiation of Carbapenem-Resistant Enterobacterales
por: Takei, Kentarou, et al.
Publicado: (2023)

In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant Enterobacterales
por: Peters, Byron K., et al.
Publicado: (2023)

Prevalence and Molecular Characterization of Metallo β-Lactamase Producing Gram-Negative Pathogens Causing Eye Infections
por: Rameshkumar, Gunasekaran, et al.
Publicado: (2022)

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase
por: Kim, Youngchang, et al.
Publicado: (2011)

Phenotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii Isolated from Pediatric Patients in Pakistan
por: Anwar, Muneeza, et al.
Publicado: (2016)

New Delhi Metallo-β-Lactamase-Mediated Carbapenem Resistance: Origin, Diagnosis, Treatment and Public Health Concern
por: Wei, Wen-Juan, et al.
Publicado: (2015)

Mortality associated with carbapenem-susceptible and Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa bacteremia
por: Persoon, Marjolein C., et al.
Publicado: (2020)

Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar
por: Takei, Satomi, et al.
Publicado: (2022)

The Mechanisms of Catalysis by Metallo β-Lactamases
por: Page, Michael I., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_odevuekee4eb7kjgk0v25qtd3p