Cargando…

Mechanism of Caspase-1 Inhibition by Four Anti-inflammatory Drugs Used in COVID-19 Treatment

The inflammatory protease caspase-1 is associated with the release of cytokines. An excessive number of cytokines (a “cytokine storm”) is a dangerous consequence of COVID-19 infection and has been indicated as being among the causes of death by COVID-19. The anti-inflammatory drug colchicine (which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caruso, Francesco, Pedersen, Jens Z., Incerpi, Sandra, Kaur, Sarjit, Belli, Stuart, Florea, Radu-Mihai, Rossi, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837144/ https://www.ncbi.nlm.nih.gov/pubmed/35163769 http://dx.doi.org/10.3390/ijms23031849

Ejemplares similares

Aromatic Polyphenol π-π Interactions with Superoxide Radicals Contribute to Radical Scavenging and Can Make Polyphenols Mimic Superoxide Dismutase Activity
por: Caruso, Francesco, et al.
Publicado: (2022)

Antioxidant Properties of Embelin in Cell Culture. Electrochemistry and Theoretical Mechanism of Scavenging. Potential Scavenging of Superoxide Radical through the Cell Membrane
por: Caruso, Francesco, et al.
Publicado: (2020)

Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone
por: Caruso, Francesco, et al.
Publicado: (2020)

Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction
por: Sakib, Raiyan, et al.
Publicado: (2023)

Scavenging of Superoxide in Aprotic Solvents of Four Isoflavones That Mimic Superoxide Dismutase
por: Yu, Sandra, et al.
Publicado: (2023)

Protection by extra virgin olive oil against oxidative stress in vitro and in vivo. Chemical and biological studies on the health benefits due to a major component of the Mediterranean diet
por: Rossi, Miriam, et al.
Publicado: (2017)

Maytenus octogona Superoxide Scavenging and Anti-Inflammatory Caspase-1 Inhibition Study Using Cyclic Voltammetry and Computational Docking Techniques
por: Caruso, Francesco, et al.
Publicado: (2023)

Emodin Scavenging of Superoxide Radical Includes π–π Interaction. X-Ray Crystal Structure, Hydrodynamic Voltammetry and Theoretical Studies
por: Rossi, Miriam, et al.
Publicado: (2020)

Azadiradione, a Component of Neem Oil, Behaves as a Superoxide Dismutase Mimic When Scavenging the Superoxide Radical, as Shown Using DFT and Hydrodynamic Voltammetry
por: Sakib, Raiyan, et al.
Publicado: (2023)

Interrelated Mechanism by Which the Methide Quinone Celastrol, Obtained from the Roots of Tripterygium wilfordii, Inhibits Main Protease 3CL(pro) of COVID-19 and Acts as Superoxide Radical Scavenger
por: Caruso, Francesco, et al.
Publicado: (2020)

Editorial: Crosstalk between thyroid hormones, analogs and ligands of integrin αvβ3 in health and disease. Who is talking now?
por: Incerpi, Sandra, et al.
Publicado: (2023)

Antioxidant properties of bee propolis and an important component, galangin, described by X-ray crystal structure, DFT-D and hydrodynamic voltammetry
por: Caruso, Francesco, et al.
Publicado: (2022)

Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles
por: Incerpi, Sandra, et al.
Publicado: (2022)

Blocking of Caspases Exerts Anti-Inflammatory Effects on Periodontal Cells
por: Panahipour, Layla, et al.
Publicado: (2022)

Draft Genome Sequences of Four Antibiotic-Resistant Salmonella Strains Isolated from Australian Red Meat Animal Species
por: Sarjit, Amreeta, et al.
Publicado: (2019)

The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer
por: Gionfra, Fabio, et al.
Publicado: (2019)

Caspase-12 and the Inflammatory Response to Yersinia pestis
por: Ferwerda, Bart, et al.
Publicado: (2009)

Serum anti-inflammatory cytokines for the evaluation of inflammatory status in endometriosis
por: Măluţan, Andrei Mihai, et al.
Publicado: (2015)

In Silico Drug Repurposing for Anti-Inflammatory Therapy: Virtual Search for Dual Inhibitors of Caspase-1 and TNF-Alpha
por: Speck-Planche, Alejandro, et al.
Publicado: (2021)

Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry †
por: Kumar, Ajit, et al.
Publicado: (2021)

X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2
por: Okoye, Ijeoma, et al.
Publicado: (2021)

Regulation and function of the caspase-1 in an inflammatory microenvironment
por: Lee, Dai-Jen, et al.
Publicado: (2015)

Senescence utilises inflammatory caspases to drive SASP
por: Wiggins, Kimberley A., et al.
Publicado: (2019)

Comments about the IJMS Special Issue: Molecular Interactions and Mechanisms of COVID-19 Inhibition
por: Caruso, Francesco, et al.
Publicado: (2022)

Nonsteroidal anti‐inflammatory drugs and pharyngitis
por: Mazzone, Stuart B, et al.
Publicado: (2022)

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
por: Bibo-Verdugo, Betsaida, et al.
Publicado: (2022)

Effective and Novel Application of Hydrodynamic Voltammetry to the Study of Superoxide Radical Scavenging by Natural Phenolic Antioxidants
por: Belli, Stuart, et al.
Publicado: (2019)

Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury
por: Liu, Bohao, et al.
Publicado: (2021)

Great balls of fire: activation and signalling of inflammatory caspases
por: Bateman, Georgia, et al.
Publicado: (2021)

Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-κB/Caspase-1 Activation in Vitro and in Vivo
por: Kim, Su-Jin, et al.
Publicado: (2010)

Heterologous Expression and Auto-Activation of Human Pro-Inflammatory Caspase-1 in Saccharomyces cerevisiae and Comparison to Caspase-8
por: Valenti, Marta, et al.
Publicado: (2021)

Non-steroidal anti-inflammatory drug use in COVID-19
por: Kragholm, Kristian, et al.
Publicado: (2021)

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3– and caspase 9–interacting sites
por: Silke, John, et al.
Publicado: (2002)

Anti-Inflammatory Activity of Four Triterpenoids Isolated from Poriae Cutis
por: Zhang, Lijia, et al.
Publicado: (2021)

Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome
por: De Luca, Roberto, et al.
Publicado: (2021)

Caspase‐8 regulates the expression of pro‐ and anti‐inflammatory cytokines in human bone marrow‐derived mesenchymal stromal cells
por: Moen, Siv H., et al.
Publicado: (2016)

Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages
por: Cho, Hui-Jin, et al.
Publicado: (2023)

Venous thromboembolism with use of hormonal contraception and non-steroidal anti-inflammatory drugs: nationwide cohort study
por: Meaidi, Amani, et al.
Publicado: (2023)

Regulatory roles of ginseng on inflammatory caspases, executioners of inflammasome activation
por: Yun, Miyong, et al.
Publicado: (2020)

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease
por: Smith, Aoife P., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lh3tnssjb8golj3lcjaglsvrf6