Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1

DNA damage by genotoxic drugs such as gemcitabine and 5-fluorouracil (5-FU) activates the ataxia telangiectasia, mutated (ATM)-Chk pathway and induces the expression of NKG2D ligands such as the MHC class I-related chain A and B (MICA/B). The mechanisms underlying this remain incompletely understood...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jingxiang, Liu, Kai, Xiao, Tianxiang, Liu, Penggang, Prinz, Richard A., Xu, Xiulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837239/
https://www.ncbi.nlm.nih.gov/pubmed/35154904
http://dx.doi.org/10.1080/2162402X.2021.2016159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837239/
https://www.ncbi.nlm.nih.gov/pubmed/35154904
http://dx.doi.org/10.1080/2162402X.2021.2016159

Ejemplares similares