p53 partial loss-of-function mutations sensitize to chemotherapy

The tumor suppressive transcription factor p53 is frequently inactivated in cancer cells by missense mutations that cluster in the DNA binding domain. 30% hit mutational hotspot residues, resulting in a complete loss of transcriptional activity and mutant p53-driven chemotherapy resistance. Of the r...

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Detalles Bibliográficos
Autores principales: Klimovich, Boris, Merle, Nastasja, Neumann, Michelle, Elmshäuser, Sabrina, Nist, Andrea, Mernberger, Marco, Kazdal, Daniel, Stenzinger, Albrecht, Timofeev, Oleg, Stiewe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837531/
https://www.ncbi.nlm.nih.gov/pubmed/34907344
http://dx.doi.org/10.1038/s41388-021-02141-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837531/
https://www.ncbi.nlm.nih.gov/pubmed/34907344
http://dx.doi.org/10.1038/s41388-021-02141-5

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