p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance

In recent years the tumor suppressor p53 has been increasingly recognized as a potent regulator of the cell metabolism and for its ability to inhibit the critical pro-survival kinases AKT and mTOR. The mechanisms through which p53 controls AKT and mTOR, however, are largely unclear. Here, we demonst...

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Detalles Bibliográficos
Autores principales: Coronel, Luis, Häckes, David, Schwab, Katjana, Riege, Konstantin, Hoffmann, Steve, Fischer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837532/
https://www.ncbi.nlm.nih.gov/pubmed/34907345
http://dx.doi.org/10.1038/s41388-021-02147-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837532/
https://www.ncbi.nlm.nih.gov/pubmed/34907345
http://dx.doi.org/10.1038/s41388-021-02147-z

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