Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which oc...

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Detalles Bibliográficos
Autores principales: Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837537/
https://www.ncbi.nlm.nih.gov/pubmed/35027740
http://dx.doi.org/10.1038/s41588-021-00996-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837537/
https://www.ncbi.nlm.nih.gov/pubmed/35027740
http://dx.doi.org/10.1038/s41588-021-00996-8

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