Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which oc...

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Autores principales: Huffman, Jennifer E., Butler-Laporte, Guillaume, Khan, Atlas, Pairo-Castineira, Erola, Drivas, Theodore G., Peloso, Gina M., Nakanishi, Tomoko, Ganna, Andrea, Verma, Anurag, Baillie, J. Kenneth, Kiryluk, Krzysztof, Richards, J. Brent, Zeberg, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837537/
https://www.ncbi.nlm.nih.gov/pubmed/35027740
http://dx.doi.org/10.1038/s41588-021-00996-8
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author Huffman, Jennifer E.
Butler-Laporte, Guillaume
Khan, Atlas
Pairo-Castineira, Erola
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Ganna, Andrea
Verma, Anurag
Baillie, J. Kenneth
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
author_facet Huffman, Jennifer E.
Butler-Laporte, Guillaume
Khan, Atlas
Pairo-Castineira, Erola
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Ganna, Andrea
Verma, Anurag
Baillie, J. Kenneth
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
author_sort Huffman, Jennifer E.
collection PubMed
description The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.
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spelling pubmed-88375372022-02-24 Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 Huffman, Jennifer E. Butler-Laporte, Guillaume Khan, Atlas Pairo-Castineira, Erola Drivas, Theodore G. Peloso, Gina M. Nakanishi, Tomoko Ganna, Andrea Verma, Anurag Baillie, J. Kenneth Kiryluk, Krzysztof Richards, J. Brent Zeberg, Hugo Nat Genet Brief Communication The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity. Nature Publishing Group US 2022-01-13 2022 /pmc/articles/PMC8837537/ /pubmed/35027740 http://dx.doi.org/10.1038/s41588-021-00996-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Huffman, Jennifer E.
Butler-Laporte, Guillaume
Khan, Atlas
Pairo-Castineira, Erola
Drivas, Theodore G.
Peloso, Gina M.
Nakanishi, Tomoko
Ganna, Andrea
Verma, Anurag
Baillie, J. Kenneth
Kiryluk, Krzysztof
Richards, J. Brent
Zeberg, Hugo
Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title_full Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title_fullStr Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title_full_unstemmed Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title_short Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
title_sort multi-ancestry fine mapping implicates oas1 splicing in risk of severe covid-19
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837537/
https://www.ncbi.nlm.nih.gov/pubmed/35027740
http://dx.doi.org/10.1038/s41588-021-00996-8
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