Cargando…

Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine

PURPOSE: This study establishes a multiphysics simulation platform for both conventional and targeted thrombolysis using tissue plasminogen activator (tPA). Based on our computational results, the effects of therapeutic parameters on the dynamics of thrombolysis and the risk of side effects are inve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Boram, Huang, Yu, Manchester, Emily Louise, Hughes, Alun D., Thom, Simon A. McG., Chen, Rongjun, Xu, Xiao Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837543/ https://www.ncbi.nlm.nih.gov/pubmed/35044591 http://dx.doi.org/10.1007/s11095-021-03161-2

Ejemplares similares

Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time
por: Gu, Boram, et al.
Publicado: (2019)

Modelling Combined Intravenous Thrombolysis and Mechanical Thrombectomy in Acute Ischaemic Stroke: Understanding the Relationship between Stent Retriever Configuration and Clot Lysis Mechanisms
por: Manchester, Emily Louise, et al.
Publicado: (2021)

Multiphysics Simulation in Drug Development and Delivery
por: Zhan, Wenbo, et al.
Publicado: (2022)

Multiphysics Modelling and Simulation for Systems Design Conference
por: Haddar, Mohamed, et al.
Publicado: (2015)

Multiphysics Simulations of the Wide Opened Waveguide Crab-cavity
por: Papke, Kai, et al.
Publicado: (2018)

Quench Simulation of Superconducting Magnets with Commercial Multiphysics Software
por: Paudel, Deepak
Publicado: (2015)

Multiphysics simulation by design for electrical machines, power electronics and drives
por: Rosu, Marius, et al.
Publicado: (2018)

Multiphysics pharmacokinetic model for targeted nanoparticles
por: Glass, Emma M., et al.
Publicado: (2022)

Numerical simulation of mechatronic sensors and actuators: finite elements for computational multiphysics
por: Kaltenbacher, Manfred
Publicado: (2015)

Multiphysics simulation of a microfluidic perfusion chamber for brain slice physiology
por: Caicedo, Hector H., et al.
Publicado: (2010)

Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
por: Okada, Jun-ichi, et al.
Publicado: (2019)

Microstructure Reconstruction and Multiphysics Dynamic Distribution Simulation of the Catalyst Layer in PEMFC
por: Zhan, Zhigang, et al.
Publicado: (2022)

Multiphysics Modeling and Simulation of a Light-Controlled Variable Damping System
por: Liu, Zhicheng, et al.
Publicado: (2023)

Multiphysical Testing of Soils and Shales
por: Laloui, Lyesse, et al.
Publicado: (2013)

Process Understanding of Plasma Electrolytic Polishing through Multiphysics Simulation and Inline Metrology
por: Danilov, Igor, et al.
Publicado: (2019)

Design of a Carangiform Swimming Robot through a Multiphysics Simulation Environment
por: Costa, Daniele, et al.
Publicado: (2020)

Multiphysics Coupling Simulation and Parameter Study of Planar Solid Oxide Fuel Cell
por: Dang, Zheng, et al.
Publicado: (2021)

Multiphysics modelling: materials, components, and systems
por: Peksen, Murat
Publicado: (2018)

Multiphysics and Multiscale Analysis for Chemotherapeutic Drug
por: Zhang, Linan, et al.
Publicado: (2015)

Microcirculatory Rarefaction in South Asians — A Potential Mechanism for Increased Cardiovascular Risk and Diabetes
por: Hughes, Alun D., et al.
Publicado: (2013)

Multiscale and multiphysics flow simulations of using the Boltzmann equation: applications to porous media and mems
por: Li, Jun
Publicado: (2019)

A Multiphysics Biventricular Cardiac Model: Simulations With a Left-Ventricular Assist Device
por: Ahmad Bakir, Azam, et al.
Publicado: (2018)

Enabling the electrochemical simulation of Li-ion battery electrodes with anisotropic tortuosity in COMSOL Multiphysics(Ⓡ)
por: Goel, Vishwas, et al.
Publicado: (2021)

Multiphysics Simulation of Crosstalk Effect in Resistive Random Access Memory with Different Metal Oxides
por: Xie, Hao, et al.
Publicado: (2022)

Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy
por: Huang, Yu, et al.
Publicado: (2021)

Evaluation of a portable retinal imaging device: towards a comparative quantitative analysis for morphological measurements of retinal blood vessels
por: Martinez-Perez, M. Elena, et al.
Publicado: (2023)

Multiphysics and multiscale modeling of microthrombosis in COVID-19
por: Li, He, et al.
Publicado: (2022)

A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations
por: Witt, Nicholas W., et al.
Publicado: (2010)

Limitations of Augmentation Index in the Assessment of Wave Reflection in Normotensive Healthy Individuals
por: Hughes, Alun D., et al.
Publicado: (2013)

Platelet-targeted thrombolysis for treatment of acute ischemic stroke
por: Palazzolo, Jason S., et al.
Publicado: (2022)

Computational Simulations of Thrombolytic Therapy in Acute Ischaemic Stroke
por: Piebalgs, Andris, et al.
Publicado: (2018)

Effects of the filter microstructure and ambient air condition on the aerodynamic dispersion of sneezing droplets: A multiscale and multiphysics simulation study
por: Lee, Kyeongeun, et al.
Publicado: (2021)

Multiphysics modelling of the LHC main quadrupole superconducting circuit
por: Pracht, Dimitri
Publicado: (2019)

The cell method for electrical engineering and multiphysics problems: an introduction
por: Alotto, Piergiorgio, et al.
Publicado: (2013)

Multiphysics Simulator for the IPMC Actuator: Mathematical Model, Finite Difference Scheme, Fast Numerical Algorithm, and Verification
por: Broyko, Anton P., et al.
Publicado: (2020)

A Multiphysics Peridynamic Model for Simulation of Fracture in Si Thin Films during Lithiation/Delithiation Cycles
por: Wang, Xiaofei, et al.
Publicado: (2021)

Optimizing Sensitivity in a Fluid-Structure Interaction-Based Microfluidic Viscometer: A Multiphysics Simulation Study
por: Mustafa, Adil, et al.
Publicado: (2023)

Platelet‐inspired nanomedicine in hemostasis thrombosis and thromboinflammation
por: Raghunathan, Shruti, et al.
Publicado: (2022)

Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury
por: Guo, Xiaoyu, et al.
Publicado: (2022)

Engineered platelets-based drug delivery platform for targeted thrombolysis
por: Wang, Songli, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hlblnn7n4hakla9pc8cov6u1li