Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment

The receptor tyrosine kinase, MERTK, plays an essential role in homeostasis of the retina via efferocytosis of shed outer nuclear segments of photoreceptors. The Royal College of Surgeons rat model of retinal degeneration has been linked to loss-of-function of MERTK, and together with the MERTK knoc...

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Detalles Bibliográficos
Autores principales: Hamm, Gregory, Maglennon, Gareth, Williamson, Beth, Macdonald, Ruth, Doherty, Ann, Jones, Stewart, Harris, Jayne, Blades, James, Harmer, Alexander R., Barton, Peter, Rawlins, Philip B., Smith, Paul, Winter-Holt, Jon, McMurray, Lindsay, Johansson, Julia, Fitzpatrick, Paul, McCoull, William, Coen, Muireann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837544/
https://www.ncbi.nlm.nih.gov/pubmed/34973110
http://dx.doi.org/10.1007/s00204-021-03197-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837544/
https://www.ncbi.nlm.nih.gov/pubmed/34973110
http://dx.doi.org/10.1007/s00204-021-03197-8

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