CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters

CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We conducted a genome-wide CRISPR knockout (KO) screen to identify genes required for CTCF-boundary activity at the HoxA cluster...

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Detalles Bibliográficos
Autores principales: Ortabozkoyun, Havva, Huang, Pin-Yao, Cho, Hyunwoo, Narendra, Varun, LeRoy, Gary, Gonzalez-Buendia, Edgar, Skok, Jane A., Tsirigos, Aristotelis, Mazzoni, Esteban O., Reinberg, Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837555/
https://www.ncbi.nlm.nih.gov/pubmed/35145304
http://dx.doi.org/10.1038/s41588-021-01008-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837555/
https://www.ncbi.nlm.nih.gov/pubmed/35145304
http://dx.doi.org/10.1038/s41588-021-01008-5

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