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CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
CCCTC-binding factor (CTCF) is critical to three-dimensional genome organization. Upon differentiation, CTCF insulates active and repressed genes within Hox gene clusters. We conducted a genome-wide CRISPR knockout (KO) screen to identify genes required for CTCF-boundary activity at the HoxA cluster...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837555/ https://www.ncbi.nlm.nih.gov/pubmed/35145304 http://dx.doi.org/10.1038/s41588-021-01008-5 |