Generative adversarial networks for construction of virtual populations of mechanistic models: simulations to study Omecamtiv Mecarbil action

Biophysical models are increasingly used to gain mechanistic insights by fitting and reproducing experimental and clinical data. The inherent variability in the recorded datasets, however, presents a key challenge. In this study, we present a novel approach, which integrates mechanistic modeling and...

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Detalles Bibliográficos
Autores principales: Parikh, Jaimit, Rumbell, Timothy, Butova, Xenia, Myachina, Tatiana, Acero, Jorge Corral, Khamzin, Svyatoslav, Solovyova, Olga, Kozloski, James, Khokhlova, Anastasia, Gurev, Viatcheslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837558/
https://www.ncbi.nlm.nih.gov/pubmed/34716531
http://dx.doi.org/10.1007/s10928-021-09787-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837558/
https://www.ncbi.nlm.nih.gov/pubmed/34716531
http://dx.doi.org/10.1007/s10928-021-09787-4

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