A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this molecule becomes access...

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Detalles Bibliográficos
Autores principales: Fleckenstein, Max, Herr, Kevin, Theiß, Franziska, Knecht, Stephan, Wienands, Laura, Brodrecht, Martin, Reggelin, Michael, Buntkowsky, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837631/
https://www.ncbi.nlm.nih.gov/pubmed/35149768
http://dx.doi.org/10.1038/s41598-022-06327-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837631/
https://www.ncbi.nlm.nih.gov/pubmed/35149768
http://dx.doi.org/10.1038/s41598-022-06327-z

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