High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson’s disease

Combining high throughput screening approaches with induced pluripotent stem cell (iPSC)-based disease modeling represents a promising unbiased strategy to identify therapies for neurodegenerative disorders. Here we applied high content imaging on iPSC-derived neurons from patients with familial Par...

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Detalles Bibliográficos
Autores principales: Antoniou, Nasia, Prodromidou, Kanella, Kouroupi, Georgia, Boumpoureka, Ioanna, Samiotaki, Martina, Panayotou, George, Xilouri, Maria, Kloukina, Ismini, Stefanis, Leonidas, Grailhe, Regis, Taoufik, Era, Matsas, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837749/
https://www.ncbi.nlm.nih.gov/pubmed/35149677
http://dx.doi.org/10.1038/s41531-022-00278-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837749/
https://www.ncbi.nlm.nih.gov/pubmed/35149677
http://dx.doi.org/10.1038/s41531-022-00278-y

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