Cargando…

High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson’s disease

Combining high throughput screening approaches with induced pluripotent stem cell (iPSC)-based disease modeling represents a promising unbiased strategy to identify therapies for neurodegenerative disorders. Here we applied high content imaging on iPSC-derived neurons from patients with familial Par...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antoniou, Nasia, Prodromidou, Kanella, Kouroupi, Georgia, Boumpoureka, Ioanna, Samiotaki, Martina, Panayotou, George, Xilouri, Maria, Kloukina, Ismini, Stefanis, Leonidas, Grailhe, Regis, Taoufik, Era, Matsas, Rebecca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837749/ https://www.ncbi.nlm.nih.gov/pubmed/35149677 http://dx.doi.org/10.1038/s41531-022-00278-y

Ejemplares similares

Patient-Derived Induced Pluripotent Stem Cell-Based Models in Parkinson’s Disease for Drug Identification
por: Kouroupi, Georgia, et al.
Publicado: (2020)

MicroRNA-934 is a novel primate-specific small non-coding RNA with neurogenic function during early development
por: Prodromidou, Kanella, et al.
Publicado: (2020)

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
por: Taoufik, Era, et al.
Publicado: (2018)

Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson’s Disease Patients
por: Elkouris, Maximilianos, et al.
Publicado: (2019)

Species-Specific miRNAs in Human Brain Development and Disease
por: Prodromidou, Kanella, et al.
Publicado: (2019)

Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson’s Disease
por: Akrioti, Elissavet, et al.
Publicado: (2022)

Novel insights into SLC25A46-related pathologies in a genetic mouse model
por: Terzenidou, Maria Eirini, et al.
Publicado: (2017)

Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions
por: Kim, Seonhee, et al.
Publicado: (2021)

Endogenous Oligodendroglial Alpha-Synuclein and TPPP/p25α Orchestrate Alpha-Synuclein Pathology in Experimental Multiple System Atrophy Models
por: Mavroeidi, Panagiota, et al.
Publicado: (2019)

Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2013)

Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2021)

3D high content imaging: high level phenotypic quantification new opportunity for drug discovery
por: Dorval, Thierry, et al.
Publicado: (2011)

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
por: Xilouri, Maria, et al.
Publicado: (2009)

In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis
por: Ouzounoglou, Eleftherios, et al.
Publicado: (2014)

Combinatory annotation of cell membrane receptors and signalling pathways of Bombyx mori prothoracic glands
por: Moulos, Panagiotis, et al.
Publicado: (2016)

Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis
por: Agallou, Maria, et al.
Publicado: (2016)

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein
por: Stamatakis, George, et al.
Publicado: (2021)

Prox1 Regulates the Notch1-Mediated Inhibition of Neurogenesis
por: Kaltezioti, Valeria, et al.
Publicado: (2010)

Cellular, Molecular and Proteomic Characteristics of Early Hepatocellular Carcinoma
por: Armakolas, Athanasios, et al.
Publicado: (2022)

Antibodies to inositol 1,4,5-triphosphate receptor 1 in patients with cerebellar disease
por: Fouka, Penelope, et al.
Publicado: (2016)

New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis
por: Papadaki, Maria, et al.
Publicado: (2019)

ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides
por: Temponeras, Ioannis, et al.
Publicado: (2022)

ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1
por: Koukoulas, Kreon, et al.
Publicado: (2021)

Glutathione–Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells’ Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis
por: Georgiou-Siafis, Sofia K., et al.
Publicado: (2022)

Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling
por: Taze, Chrysa, et al.
Publicado: (2022)

A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway
por: Antoniou, Nasia, et al.
Publicado: (2018)

CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons
por: Aravantinou-Fatorou, Katerina, et al.
Publicado: (2015)

FLIM-FRET analyzer: open source software for automation of lifetime-based FRET analysis
por: Kim, Jiho, et al.
Publicado: (2017)

Pharmacological intervention in a transgenic mouse model improves Alzheimer’s-associated pathological phenotype: Involvement of proteasome activation
por: Djordjevic, Aleksandra N. Mladenovic, et al.
Publicado: (2020)

ProteoSign v2: a faster and evolved user-friendly online tool for statistical analyses of differential proteomics
por: Theodorakis, Evangelos, et al.
Publicado: (2021)

Differential detection of nuclear envelope autoantibodies in primary biliary cirrhosis using routine and alternative methods
por: Tsangaridou, Elena, et al.
Publicado: (2010)

Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy
por: Stanojevic, Aleksandra, et al.
Publicado: (2023)

Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases
por: Vakrakou, Aigli G., et al.
Publicado: (2022)

Differential intracellular trafficking of extracellular vesicles in microglia and astrocytes
por: Pantazopoulou, Marina, et al.
Publicado: (2023)

Optimization of BRET saturation assays for robust and sensitive cytosolic protein–protein interaction studies
por: Besson, Benoit, et al.
Publicado: (2022)

Increased autophagy/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms
por: Daskalakis, Kosmas, et al.
Publicado: (2020)

Proteomic analysis upon peach fruit infection with Monilinia fructicola and M. laxa identify responses contributing to brown rot resistance
por: Papavasileiou, Antonios, et al.
Publicado: (2020)

Unraveling Interactions of the Necrotrophic Fungal Species Botrytis cinerea With 1-Methylcyclopropene or Ozone-Treated Apple Fruit Using Proteomic Analysis
por: Testempasis, Stefanos, et al.
Publicado: (2021)

Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology
por: Stergiou, Ioanna E., et al.
Publicado: (2021)

Cutaneous Vasculopathy in a COVID-19 Critically Ill Patient: A Histologic, Immunohistochemical, and Electron Microscopy Study
por: Kyriakoudi, Anna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sjq088g1cearc20lue0uandjs7