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Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease

SIRT1 is an NAD(+)-dependent class III histone deacetylase that is abundantly expressed in the kidney, where it modulates gene expression, apoptosis, energy homeostasis, autophagy, acute stress responses, and mitochondrial biogenesis. Alterations in SIRT1 activity and NAD(+) metabolism are frequentl...

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Detalles Bibliográficos
Autores principales: Tovar-Palacio, Claudia, Noriega, Lilia G., Mercado, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837945/
https://www.ncbi.nlm.nih.gov/pubmed/35277012
http://dx.doi.org/10.3390/nu14030653