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Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease
SIRT1 is an NAD(+)-dependent class III histone deacetylase that is abundantly expressed in the kidney, where it modulates gene expression, apoptosis, energy homeostasis, autophagy, acute stress responses, and mitochondrial biogenesis. Alterations in SIRT1 activity and NAD(+) metabolism are frequentl...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837945/ https://www.ncbi.nlm.nih.gov/pubmed/35277012 http://dx.doi.org/10.3390/nu14030653 |