Cargando…

Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives

The urease enzyme has been an important target for the discovery of effective pharmacological and agricultural products. Thirteen regio-selectively alkylated benzimidazole-2-thione derivatives have been designed to carry the essential features of urease inhibitors. The urease enzyme was isolated fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mohammed, Salih Osman, El Ashry, El Sayed H., Khalid, Asaad, Amer, Mohamed R., Metwaly, Ahmed M., Eissa, Ibrahim H., Elkaeed, Eslam B., Elshobaky, Ahmed, Hafez, Elsayed E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838460/ https://www.ncbi.nlm.nih.gov/pubmed/35164122 http://dx.doi.org/10.3390/molecules27030865

Ejemplares similares

Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
por: El Ashry, El Sayed H., et al.
Publicado: (2015)

In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10
por: Eissa, Ibrahim H., et al.
Publicado: (2021)

Perhydrobenzimidazole-2-thione
por: Liu, YingChun, et al.
Publicado: (2009)

New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies
por: Mumtaz, Sundas, et al.
Publicado: (2022)

In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies
por: Alesawy, Mohamed S., et al.
Publicado: (2021)

1H-Benzimidazole-2(3H)-thione
por: Wang, De-Cai, et al.
Publicado: (2009)

Regio- and Stereoselective Electrochemical Alkylation of Morita–Baylis–Hillman Adducts
por: Bertuzzi, Giulio, et al.
Publicado: (2022)

In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (M(pro))
por: Alesawy, Mohamed S., et al.
Publicado: (2021)

The Inhibitory Potential of 2′-dihalo Ribonucleotides against HCV: Molecular Docking, Molecular Simulations, MM-BPSA, and DFT Studies
por: Khalil, Ahmed, et al.
Publicado: (2022)

Discovery of Potential SARS-CoV-2 Papain-like Protease Natural Inhibitors Employing a Multi-Phase In Silico Approach
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Regioselectivity of the alkylation of S-substituted 1,2,4-triazoles with dihaloalkanes
por: Boraei, Ahmed T. A., et al.
Publicado: (2016)

Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19)
por: El-Demerdash, Amr, et al.
Publicado: (2021)

The Computational Preventive Potential of the Rare Flavonoid, Patuletin, Isolated from Tagetes patula, against SARS-CoV-2
por: Metwaly, Ahmed M., et al.
Publicado: (2022)

1-Methyl-1H-benzimidazole-2(3H)-thione
por: Khan, Hizbullah, et al.
Publicado: (2008)

Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2′-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
por: Eissa, Ibrahim H., et al.
Publicado: (2022)

The Discovery of Potential SARS-CoV-2 Natural Inhibitors among 4924 African Metabolites Targeting the Papain-like Protease: A Multi-Phase In Silico Approach
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor
por: Al-Karmalawy, Ahmed A., et al.
Publicado: (2021)

A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main Protease
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Regio- and diastereoselective dearomatizations of N-alkyl activated azaarenes: the maximization of the reactive sites
por: Miao, Hong-Jie, et al.
Publicado: (2019)

A Facile and Efficient Procedure for the Synthesis of New Benzimidazole-2-thione Derivatives
por: Rivera, Augusto, et al.
Publicado: (2012)

Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers
por: Elzahabi, Heba S. A., et al.
Publicado: (2022)

The effect of S-alkylation on organocatalytic enamine activation through imidazolidine-4-thiones
por: Hensinger, Magenta J., et al.
Publicado: (2023)

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies
por: Taghour, Mohammed S., et al.
Publicado: (2022)

Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2,4-dione derivatives as potential antitumor VEGFR-2 inhibitors
por: Elkady, Hazem, et al.
Publicado: (2023)

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
por: Sobh, Eman A., et al.
Publicado: (2023)

Synthesis, density functional theory (DFT) studies and urease inhibition activity of chiral benzimidazoles
por: Aman, Hasil, et al.
Publicado: (2020)

Extraction, purification, kinetic and thermodynamic properties of urease from germinating Pisum Sativum L. seeds
por: EL-Hefnawy, Mohamed E, et al.
Publicado: (2014)

Aminosilanes derived from 1H-benzimidazole-2(3H)-thione
por: Palomo-Molina, Juliana, et al.
Publicado: (2015)

Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer
por: Eissa, Ibrahim H, et al.
Publicado: (2023)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway
por: Taghour, Mohammed S., et al.
Publicado: (2022)

New Anticancer Theobromine Derivative Targeting EGFR(WT) and EGFR(T790M): Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2
por: El-Metwally, Souad A., et al.
Publicado: (2023)

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
por: Yousef, Reda G., et al.
Publicado: (2022)

Combined In Silico and Experimental Investigations of Resveratrol Encapsulation by Beta-Cyclodextrin
por: Iskineyeva, Ainara, et al.
Publicado: (2022)

Synthesis and Antibacterial Activities of 1-Alkyl-3-methacryloyl (Acryloyl) of Benzimidazolone (Thione) Derivatives
por: Wei, Shaopeng, et al.
Publicado: (2012)

Chemo- and regio-divergent access to fluorinated 1-alkyl and 1-acyl triazenes from alkynyl triazenes
por: Tan, Jin-Fay, et al.
Publicado: (2022)

1,3-Bis(ethoxymethyl)-1H-benzimidazole-2(3H)-thione
por: Rivera, Augusto, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_rd1bopmlcggsa46ak5fu0l9b8g