Design, Synthesis and Cytotoxicity of Thiazole-Based Stilbene Analogs as Novel DNA Topoisomerase IB Inhibitors

A series of new thiazole-based stilbene analogs were designed, synthesized and evaluated for DNA topoisomerase IB (Top1) inhibitory activity. Top1-mediated relaxation assays showed that the synthesized compounds possessed variable Top1 inhibitory activity. Among them, (E)-2-(3-methylstyryl)-4-(4-flu...

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Detalles Bibliográficos
Autores principales: Liu, Jin-Chuan, Chen, Bo, Yang, Jia-Lin, Weng, Jian-Quan, Yu, Qian, Hu, De-Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838847/
https://www.ncbi.nlm.nih.gov/pubmed/35164276
http://dx.doi.org/10.3390/molecules27031009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838847/
https://www.ncbi.nlm.nih.gov/pubmed/35164276
http://dx.doi.org/10.3390/molecules27031009

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