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Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study
The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this st...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838962/ https://www.ncbi.nlm.nih.gov/pubmed/35276764 http://dx.doi.org/10.3390/nu14030405 |
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author | Valls, Rosa M. Companys, Judit Calderón-Pérez, Lorena Salamanca, Patricia Pla-Pagà, Laura Sandoval-Ramírez, Berner Andrée Bueno, Antonio Puzo, Jose Crescenti, Anna del Bas, Josep M. Caimari, Antoni Salamanca, Aurora Espinel, Alberto E. Pedret, Anna Arola, Lluís Solà, Rosa |
author_facet | Valls, Rosa M. Companys, Judit Calderón-Pérez, Lorena Salamanca, Patricia Pla-Pagà, Laura Sandoval-Ramírez, Berner Andrée Bueno, Antonio Puzo, Jose Crescenti, Anna del Bas, Josep M. Caimari, Antoni Salamanca, Aurora Espinel, Alberto E. Pedret, Anna Arola, Lluís Solà, Rosa |
author_sort | Valls, Rosa M. |
collection | PubMed |
description | The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this study was to assess the effect of daily intake of a well-characterized ABG extract with a standardized S-allyl-L-cysteine (SAC) yield in combination with dietary recommendations regarding CVD risk factors in individuals with moderate hypercholesterolemia. Sixty-seven hypercholesterolemic individuals with low-density lipoprotein cholesterol levels ≥115 mg/dL were randomized in a crossover, double-blind, sustained, and controlled intervention study. The participants consumed 250 mg (1.25 mg SAC)/tablet/day ABG or a placebo for 6 weeks, with 3 weeks of washout. Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention. At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg. The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia. The potential beneficial effects of ABG may contribute to obtaining an optimal DBP. |
format | Online Article Text |
id | pubmed-8838962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88389622022-02-13 Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study Valls, Rosa M. Companys, Judit Calderón-Pérez, Lorena Salamanca, Patricia Pla-Pagà, Laura Sandoval-Ramírez, Berner Andrée Bueno, Antonio Puzo, Jose Crescenti, Anna del Bas, Josep M. Caimari, Antoni Salamanca, Aurora Espinel, Alberto E. Pedret, Anna Arola, Lluís Solà, Rosa Nutrients Article The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this study was to assess the effect of daily intake of a well-characterized ABG extract with a standardized S-allyl-L-cysteine (SAC) yield in combination with dietary recommendations regarding CVD risk factors in individuals with moderate hypercholesterolemia. Sixty-seven hypercholesterolemic individuals with low-density lipoprotein cholesterol levels ≥115 mg/dL were randomized in a crossover, double-blind, sustained, and controlled intervention study. The participants consumed 250 mg (1.25 mg SAC)/tablet/day ABG or a placebo for 6 weeks, with 3 weeks of washout. Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention. At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg. The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia. The potential beneficial effects of ABG may contribute to obtaining an optimal DBP. MDPI 2022-01-18 /pmc/articles/PMC8838962/ /pubmed/35276764 http://dx.doi.org/10.3390/nu14030405 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Valls, Rosa M. Companys, Judit Calderón-Pérez, Lorena Salamanca, Patricia Pla-Pagà, Laura Sandoval-Ramírez, Berner Andrée Bueno, Antonio Puzo, Jose Crescenti, Anna del Bas, Josep M. Caimari, Antoni Salamanca, Aurora Espinel, Alberto E. Pedret, Anna Arola, Lluís Solà, Rosa Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title | Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title_full | Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title_fullStr | Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title_full_unstemmed | Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title_short | Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study |
title_sort | effects of an optimized aged garlic extract on cardiovascular disease risk factors in moderate hypercholesterolemic subjects: a randomized, crossover, double-blind, sustainedand controlled study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8838962/ https://www.ncbi.nlm.nih.gov/pubmed/35276764 http://dx.doi.org/10.3390/nu14030405 |
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