Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents

The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs...

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Detalles Bibliográficos
Autores principales: Pazos, Mariana, Dibello, Estefania, Mesa, Juan Manuel, Sames, Dalibor, Comini, Marcelo Alberto, Seoane, Gustavo, Carrera, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839081/
https://www.ncbi.nlm.nih.gov/pubmed/35164094
http://dx.doi.org/10.3390/molecules27030829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839081/
https://www.ncbi.nlm.nih.gov/pubmed/35164094
http://dx.doi.org/10.3390/molecules27030829

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