Cargando…

Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents

The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pazos, Mariana, Dibello, Estefania, Mesa, Juan Manuel, Sames, Dalibor, Comini, Marcelo Alberto, Seoane, Gustavo, Carrera, Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839081/ https://www.ncbi.nlm.nih.gov/pubmed/35164094 http://dx.doi.org/10.3390/molecules27030829

Ejemplares similares

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits
por: Marton, Soledad, et al.
Publicado: (2019)

Efficient Access to the Iboga Skeleton: Optimized Procedure to Obtain Voacangine from Voacanga africana Root Bark
por: González, Bruno, et al.
Publicado: (2021)

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant
por: Farrow, Scott C., et al.
Publicado: (2019)

Structural Basis of Cycloaddition in Biosynthesis of Iboga and Aspidosperma Alkaloids
por: Caputi, Lorenzo, et al.
Publicado: (2020)

Stereoselective Synthesis of Isoquinuclidines through an Aza-[4 + 2] Cycloaddition of Chiral Cyclic 2-Amidodienes
por: Fang, Li-Chao, et al.
Publicado: (2014)

Chemoenzymatic approaches to plant natural product inspired compounds
por: Roddan, Rebecca, et al.
Publicado: (2022)

New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata
por: Li, Xiang-Mei, et al.
Publicado: (2019)

Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums
por: Zhang, Yun, et al.
Publicado: (2016)

Effect of Iboga Alkaloids on µ-Opioid Receptor-Coupled G Protein Activation
por: Antonio, Tamara, et al.
Publicado: (2013)

The indole motif is essential for the antitrypanosomal activity of N(5)-substituted paullones
por: Ihnatenko, Irina, et al.
Publicado: (2023)

Chemoenzymatic Synthesis of Tenofovir
por: Zdun, Beata, et al.
Publicado: (2023)

Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine
por: Qu, Yang, et al.
Publicado: (2018)

Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids
por: Pickl, Mathias, et al.
Publicado: (2021)

Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from Tabernanthe iboga
por: Farrow, Scott C., et al.
Publicado: (2018)

Two Novel Iboga-Type and an Oxindole Glucuronide Alkaloid from Tabernaemontana peduncularis Disclose Related Biosynthetic Pathways to Tabernaemontana divaricata
por: Traxler, Florian, et al.
Publicado: (2023)

Chemoenzymatic Synthesis of Oligohyaluronan–Lipid Conjugates
por: Ruhela, Dipali, et al.
Publicado: (2014)

Recent Advances in Chemoenzymatic Peptide Syntheses
por: Yazawa, Kenjiro, et al.
Publicado: (2014)

An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
por: Demiray, Melodi, et al.
Publicado: (2017)

Droplet Microfluidic Device for Chemoenzymatic Sensing
por: Yakimov, Anton S., et al.
Publicado: (2022)

Chemoenzymatic Synthesis of ortho-, meta-, and para-Substituted Derivatives of l-threo-3-Benzyloxyaspartate, An Important Glutamate Transporter Blocker
por: de Villiers, Jandré, et al.
Publicado: (2015)

The Future of GDNF in Parkinson's Disease
por: Manfredsson, Fredric P., et al.
Publicado: (2020)

Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice
por: García-Caballero, Cristina, et al.
Publicado: (2018)

An Efficient Chemoenzymatic Approach towards the Synthesis of Rugulactone
por: Tyrikos-Ergas, Theodore, et al.
Publicado: (2018)

Thiol-free chemoenzymatic synthesis of β-ketosulfides
por: Heredia, Adrián A, et al.
Publicado: (2019)

Chemoenzymatic Synthesis of the Most Pleasant Stereoisomer of Jessemal
por: Venturi, Silvia, et al.
Publicado: (2022)

Chemoenzymatic Synthesis of Indole-Containing Acyloin Derivatives
por: Alrashdi, Saad, et al.
Publicado: (2023)

Current Progress in the Chemoenzymatic Synthesis of Natural Products
por: Vanable, Evan P., et al.
Publicado: (2022)

The GDNF Family: A Role in Cancer?
por: Fielder, Graeme C., et al.
Publicado: (2017)

Multi-Step Enzyme Catalysis: Biotransformations and Chemoenzymatic Synthesis
por: Garcia-Junceda, Eduardo
Publicado: (2008)

Chemoenzymatic Synthesis and Chemical Recycling of Poly(ester-urethane)s
por: Hayashi, Hiroto, et al.
Publicado: (2011)

Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
por: Meng, Xin, et al.
Publicado: (2014)

Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid
por: Abdulmalek, Emilia, et al.
Publicado: (2014)

Fluorous-Assisted Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides
por: Cai, Chao, et al.
Publicado: (2014)

Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags
por: Smith, Elizabeth L., et al.
Publicado: (2014)

Chemoenzymatic Kinetic resolution of (R)-malathion in aqueous media
por: Enríquez-Núñez, Carlos A., et al.
Publicado: (2015)

Efficient chemoenzymatic synthesis of an N-glycan isomer library
por: Li, Lei, et al.
Publicado: (2015)

Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites
por: Valentová, Kateřina, et al.
Publicado: (2017)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
por: Zhao, Jianxiong, et al.
Publicado: (2018)

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives
por: Zheng, Hui, et al.
Publicado: (2013)

Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium
por: Dander, Jacob E., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1cg7lpamiof8ujlmhkp4ovp00m