Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile

Using two ways of functionalizing amiridine—acylation with chloroacetic acid chloride and reaction with thiophosgene—we have synthesized new homobivalent bis-amiridines joined by two different spacers—bis-N-acyl-alkylene (3) and bis-N-thiourea-alkylene (5) —as potential multifunctional agents for th...

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Detalles Bibliográficos
Autores principales: Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Rudakova, Elena V., Lushchekina, Sofya V., Astakhova, Tatiana Yu., Serkov, Igor V., Proshin, Alexey N., Radchenko, Eugene V., Palyulin, Vladimir A., Korabecny, Jan, Soukup, Ondrej, Bachurin, Sergey O., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839189/
https://www.ncbi.nlm.nih.gov/pubmed/35164325
http://dx.doi.org/10.3390/molecules27031060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839189/
https://www.ncbi.nlm.nih.gov/pubmed/35164325
http://dx.doi.org/10.3390/molecules27031060

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