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Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients

The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case. Thus, we aimed...

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Autores principales: Scarcella, Marialaura, Scarpellini, Emidio, Ascani, Alessandra, Commissari, Rita, Scorcella, Claudia, Zanetti, Michela, Parisi, Amilcare, Monti, Riccardo, Milic, Natasa, Donati, Abele, Luzza, Francesco, De Robertis, Edoardo, Abenavoli, Ludovico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839228/
https://www.ncbi.nlm.nih.gov/pubmed/35276795
http://dx.doi.org/10.3390/nu14030437
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author Scarcella, Marialaura
Scarpellini, Emidio
Ascani, Alessandra
Commissari, Rita
Scorcella, Claudia
Zanetti, Michela
Parisi, Amilcare
Monti, Riccardo
Milic, Natasa
Donati, Abele
Luzza, Francesco
De Robertis, Edoardo
Abenavoli, Ludovico
author_facet Scarcella, Marialaura
Scarpellini, Emidio
Ascani, Alessandra
Commissari, Rita
Scorcella, Claudia
Zanetti, Michela
Parisi, Amilcare
Monti, Riccardo
Milic, Natasa
Donati, Abele
Luzza, Francesco
De Robertis, Edoardo
Abenavoli, Ludovico
author_sort Scarcella, Marialaura
collection PubMed
description The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case. Thus, we aimed to assess the effects of an adequate nutritional protocol rich in whey protein on nutritional and inflammatory status, extubating time, and mortality of critically ill COVID-19 patients (CICP). Methods: A prospective single-center exploratory observational study was undertaken on 32 consecutive CICP admitted to the ICU of Santa Maria Hospital, Terni, Italy, and treated with whey protein-enriched formula. Patients’ demographics, nutritional status, indexes of inflammation, daily pre-albumin serum levels, duration of mechanical ventilation, and mortality were recorded. Results: Thirty-two patients were enrolled. Ninety-five percent of them showed a gradual reduction in C-reactive protein (CRP) values and increase in pre-albumin levels after the whey protein-enriched formula. Prealbumin levels were not correlated with a better nutritional status but with a shorter extubating time and better survival. Conclusions: An adequate administration of whey protein during COVID-19 patients’ ICU stays can provide fast achievement of protein targets, reducing the duration of mechanical ventilation, and improving inflammatory status and ICU survival. Further prospective and large-scale, controlled studies are needed to confirm these results.
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spelling pubmed-88392282022-02-13 Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients Scarcella, Marialaura Scarpellini, Emidio Ascani, Alessandra Commissari, Rita Scorcella, Claudia Zanetti, Michela Parisi, Amilcare Monti, Riccardo Milic, Natasa Donati, Abele Luzza, Francesco De Robertis, Edoardo Abenavoli, Ludovico Nutrients Article The novel SARS-CoV-2 virus has led to a severe pandemic, starting from early 2020. Intensive care (ICU) management of the COVID-19 disease is difficult with high morbidity and mortality. Early nutritional support, especially with whey protein, seems to be crucial in this medical case. Thus, we aimed to assess the effects of an adequate nutritional protocol rich in whey protein on nutritional and inflammatory status, extubating time, and mortality of critically ill COVID-19 patients (CICP). Methods: A prospective single-center exploratory observational study was undertaken on 32 consecutive CICP admitted to the ICU of Santa Maria Hospital, Terni, Italy, and treated with whey protein-enriched formula. Patients’ demographics, nutritional status, indexes of inflammation, daily pre-albumin serum levels, duration of mechanical ventilation, and mortality were recorded. Results: Thirty-two patients were enrolled. Ninety-five percent of them showed a gradual reduction in C-reactive protein (CRP) values and increase in pre-albumin levels after the whey protein-enriched formula. Prealbumin levels were not correlated with a better nutritional status but with a shorter extubating time and better survival. Conclusions: An adequate administration of whey protein during COVID-19 patients’ ICU stays can provide fast achievement of protein targets, reducing the duration of mechanical ventilation, and improving inflammatory status and ICU survival. Further prospective and large-scale, controlled studies are needed to confirm these results. MDPI 2022-01-19 /pmc/articles/PMC8839228/ /pubmed/35276795 http://dx.doi.org/10.3390/nu14030437 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scarcella, Marialaura
Scarpellini, Emidio
Ascani, Alessandra
Commissari, Rita
Scorcella, Claudia
Zanetti, Michela
Parisi, Amilcare
Monti, Riccardo
Milic, Natasa
Donati, Abele
Luzza, Francesco
De Robertis, Edoardo
Abenavoli, Ludovico
Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title_full Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title_fullStr Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title_full_unstemmed Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title_short Effect of Whey Proteins on Malnutrition and Extubating Time of Critically Ill COVID-19 Patients
title_sort effect of whey proteins on malnutrition and extubating time of critically ill covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839228/
https://www.ncbi.nlm.nih.gov/pubmed/35276795
http://dx.doi.org/10.3390/nu14030437
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