A Novel Docetaxel-Biotin Chemical Conjugate for Prostate Cancer Treatment

A novel conjugate of docetaxel and biotin (designated as IDD-1010) was designed and chemically synthesized via an ester linkage at position 2’ carbon in docetaxel. The synthesized pure IDD-1010 exhibits a potent anti-cancer activity in in vitro and in vivo studies. At 10 nM, IDD-1010 has induced inc...

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Detalles Bibliográficos
Autores principales: Rayan, Mahmoud, Shadafny, Seba, Falah, Adam, Falah, Mizied, Abu-Lafi, Saleh, Asli, Sare, Rayan, Anwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839329/
https://www.ncbi.nlm.nih.gov/pubmed/35164226
http://dx.doi.org/10.3390/molecules27030961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839329/
https://www.ncbi.nlm.nih.gov/pubmed/35164226
http://dx.doi.org/10.3390/molecules27030961

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