Identification of the New Metabolite of Nebivolol Using Liquid Chromatography Coupled with High-Resolution Mass Spectrometry and Chemometrics

In this study, the phase I hepatic metabolism pathway of a cardiovascular drug nebivolol was proposed on the basis of a human liver microsomes assay with the use of LC-HR-MS coupled with the chemometric method. Six biotransformation products were found with the assistance of chemometric analysis. Fi...

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Detalles Bibliográficos
Autores principales: Trawiński, Jakub, Wroński, Michał, Gawlik, Maciej, Skibiński, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839339/
https://www.ncbi.nlm.nih.gov/pubmed/35164027
http://dx.doi.org/10.3390/molecules27030763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839339/
https://www.ncbi.nlm.nih.gov/pubmed/35164027
http://dx.doi.org/10.3390/molecules27030763

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