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Investigating the Broad Matrix-Gate Network in the Mitochondrial ADP/ATP Carrier through Molecular Dynamics Simulations

The mitochondrial ADP/ATP carrier (AAC) exports ATP and imports ADP through alternating between cytosol-open (c-) and matrix-open (m-) states. The salt bridge networks near the matrix side (m-gate) and cytosol side (c-gate) are thought to be crucial for state transitions, yet our knowledge on these...

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Detalles Bibliográficos
Autores principales: Yao, Shihao, Ma, Boyuan, Yi, Qiuzi, Guan, Min-Xin, Cang, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839422/
https://www.ncbi.nlm.nih.gov/pubmed/35164338
http://dx.doi.org/10.3390/molecules27031071