Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution

An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize hydroxyalkylation on heterocycles such as indoles or thiophen...

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Detalles Bibliográficos
Autores principales: Duvauchelle, Valentin, Bénimélis, David, Meffre, Patrick, Benfodda, Zohra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839828/
https://www.ncbi.nlm.nih.gov/pubmed/35164190
http://dx.doi.org/10.3390/molecules27030925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839828/
https://www.ncbi.nlm.nih.gov/pubmed/35164190
http://dx.doi.org/10.3390/molecules27030925

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