Cargando…

The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding

Tuberculosis (TB), caused by the Mycobacterium tuberculosis infection, continues to be a leading cause of morbidity and mortality in developing countries. Resistance to the first-line anti-TB drugs, isoniazid (INH) and rifampicin (RIF), is a major drawback to effective TB treatment. Genetic mutation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amusengeri, Arnold, Khan, Asifullah, Tastan Bishop, Özlem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839920/ https://www.ncbi.nlm.nih.gov/pubmed/35164151 http://dx.doi.org/10.3390/molecules27030885

Ejemplares similares

Reevaluating Rifampicin Breakpoint Concentrations for Mycobacterium tuberculosis Isolates with Disputed rpoB Mutations and Discordant Susceptibility Phenotypes
por: Wang, Wei, et al.
Publicado: (2022)

HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis
por: Loiseau, Chloé, et al.
Publicado: (2020)

A Glutamine Insertion at Codon 432 of RpoB Confers Rifampicin Resistance in Mycobacterium tuberculosis
por: Lai, Li-Yin, et al.
Publicado: (2020)

rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis
por: Li, Ma-chao, et al.
Publicado: (2021)

Detection of Mycobacterium tuberculosis Rifampicin Resistance Conferred by Borderline rpoB Mutations: Xpert MTB/RIF is Superior to Phenotypic Drug Susceptibility Testing
por: Xia, Hui, et al.
Publicado: (2022)

Drug resistance and the genotypic characteristics of rpoB and katG in rifampicin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates in central Vietnam
por: Nguyen, Thi Binh Nguyen, et al.
Publicado: (2023)

Variable ability of rapid tests to detect Mycobacterium tuberculosis rpoB mutations conferring phenotypically occult rifampicin resistance
por: Torrea, Gabriela, et al.
Publicado: (2019)

Status of rpoB gene mutation associated with rifampicin-resistant Mycobacterium tuberculosis isolated in a rural setting in Nepal
por: Adhikari, Saroj, et al.
Publicado: (2021)

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region
por: Ma, Pengjiao, et al.
Publicado: (2021)

Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic
por: Isakova, Jainagul, et al.
Publicado: (2018)

rpoB Mutations Causing Discordant Rifampicin Susceptibility in Mycobacterium tuberculosis: Retrospective Analysis of Prevalence, Phenotypic, Genotypic, and Treatment Outcomes
por: Mvelase, Nomonde R, et al.
Publicado: (2019)

Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons
por: Bobba, Suhas, et al.
Publicado: (2023)

Borderline rpoB mutations transmit at the same rate as common rpoB mutations in a tuberculosis cohort in Bangladesh
por: Lempens, Pauline, et al.
Publicado: (2023)

Variations in the occurrence of specific rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolates from patients of different ethnic groups in Kuwait
por: Ahmad, Suhail, et al.
Publicado: (2012)

Detection of Mycobacterium tuberculosis in extrapulmonary biopsy samples using PCR targeting IS6110, rpoB, and nested-rpoB PCR Cloning
por: Meghdadi, Hossein, et al.
Publicado: (2015)

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin
por: Zaczek, Anna, et al.
Publicado: (2009)

Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates
por: Jing, Wei, et al.
Publicado: (2017)

rpoB Mutations are Associated with Variable Levels of Rifampin and Rifabutin Resistance in Mycobacterium tuberculosis
por: Li, Ma-Chao, et al.
Publicado: (2022)

Multiple rpoB Mutants of Mycobacterium tuberculosis and Second-order Selection
por: Mokrousov, Igor
Publicado: (2004)

Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug-resistant tuberculosis
por: Al-Mutairi, Noura M., et al.
Publicado: (2019)

Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB
por: Brandis, Gerrit, et al.
Publicado: (2018)

Commentary: Rifabutin Resistance Associated with Double Mutations in rpoB Gene in Mycobacterium tuberculosis Isolates
por: Sharma, Sandeep, et al.
Publicado: (2017)

Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea
por: Jo, Kyung-Wook, et al.
Publicado: (2017)

Rifampicin-Resistance Mutations in the rpoB Gene in Bacillus velezensis CC09 have Pleiotropic Effects
por: Cai, Xun-Chao, et al.
Publicado: (2017)

rpoB mutations conferring rifampicin-resistance affect growth, stress response and motility in Vibrio vulnificus
por: Cutugno, Laura, et al.
Publicado: (2020)

Distribution and Frequency of rpoB Mutations Detected by Xpert MTB/RIF Assay Among Beijing and Non-Beijing Rifampicin Resistant Mycobacterium tuberculosis Isolates in Bangladesh
por: Uddin, Mohammad Khaja Mafij, et al.
Publicado: (2020)

GeneXpert MTB/RIF Ultra performance to detect uncommon rpoB mutations in Mycobacterium tuberculosis
por: Rigouts, Leen, et al.
Publicado: (2023)

Understanding the Pyrimethamine Drug Resistance Mechanism via Combined Molecular Dynamics and Dynamic Residue Network Analysis
por: Amusengeri, Arnold, et al.
Publicado: (2020)

Determination of Potentially Novel Compensatory Mutations in rpoC Associated with Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis Clinical Isolates from Peru
por: Vargas, Ana Paula, et al.
Publicado: (2020)

Rifampicin Resistance Associated with rpoB Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020
por: Schaeffer, Justine, et al.
Publicado: (2022)

Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert MTB/RIF in Khyber Pakhtunkhwa, Pakistan: a retrospective study
por: Ullah, Irfan, et al.
Publicado: (2016)

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D
por: Campodónico, Victoria L., et al.
Publicado: (2018)

Investigation of the rpoB Mutations Causing Rifampin Resistance by Rapid Screening in Mycobacterium Tuberculosis in North-East of Iran
por: Tajbakhsh, Amir, et al.
Publicado: (2018)

rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates from rural areas of Zhejiang, China
por: Zeng, Mei-Chun, et al.
Publicado: (2021)

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
por: Zhu, Jun-Hao, et al.
Publicado: (2018)

Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert(®)MTB/RIF in Kampala, Uganda: a retrospective study
por: Mboowa, Gerald, et al.
Publicado: (2014)

Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis
por: Cummings, Michael P, et al.
Publicado: (2004)

Epidemiology of Rifampicin Resistant Tuberculosis and Common Mutations in rpoB Gene of Mycobacterium tuberculosis: A Retrospective Study from Six Districts of Punjab (India) Using Xpert MTB/RIF Assay
por: Kaur, Ramandeep, et al.
Publicado: (2016)

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility
por: Patel, Yesha, et al.
Publicado: (2023)

Characterization of Molecular Evolution in Multi-Drug Resistant of Mycobacterium tuberculosis by rpoB Gene in Patient with Active Pulmonary Tuberculosis from Iranian Isolates
por: Saeed, Zaker Bostanabad, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_tahbbgtbaccql872kj7go2pkpk