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Measurement of Secondary Structure Changes in Poly-L-lysine and Lysozyme during Acoustically Levitated Single Droplet Drying Experiments by In Situ Raman Spectroscopy

Drying processes such as spray drying, as commonly used in the pharmaceutical industry to convert protein-based drugs into their particulate form, can lead to an irreversible loss of protein activity caused by protein secondary structure changes. Due to the nature of these processes (high droplet nu...

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Detalles Bibliográficos
Autores principales: Perlitz, Julian F. A., Gentner, Lukas, Braeuer, Phillipp A. B., Will, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839924/
https://www.ncbi.nlm.nih.gov/pubmed/35161856
http://dx.doi.org/10.3390/s22031111