Pharmacokinetic Characterization of the DDAH1 Inhibitors ZST316 and ZST152 in Mice Using a HPLC-MS/MS Method

The pharmacokinetic profile of ZST316 and ZST152, arginine analogues with inhibitory activity towards human dimethylarginine dimethylaminohydrolase-1 (DDAH1), was investigated in mice using a newly developed HPLC-MS/MS method. The method proved to be reproducible, precise, and accurate for the measu...

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Detalles Bibliográficos
Autores principales: Mangoni, Arduino A., Ceruti, Tommaso, Frapolli, Roberta, Russo, Massimo, Fichera, Stefania, Zucchetti, Massimo, Tommasi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840040/
https://www.ncbi.nlm.nih.gov/pubmed/35164277
http://dx.doi.org/10.3390/molecules27031017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840040/
https://www.ncbi.nlm.nih.gov/pubmed/35164277
http://dx.doi.org/10.3390/molecules27031017

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