Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model

Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (AGS), focusing on the modulation of angiogeni...

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Detalles Bibliográficos
Autores principales: Ricci, Alessia, Gallorini, Marialucia, Del Bufalo, Donatella, Cataldi, Amelia, D’Agostino, Ilaria, Carradori, Simone, Zara, Susi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840372/
https://www.ncbi.nlm.nih.gov/pubmed/35164221
http://dx.doi.org/10.3390/molecules27030957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840372/
https://www.ncbi.nlm.nih.gov/pubmed/35164221
http://dx.doi.org/10.3390/molecules27030957

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