Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors

Accumulated preclinical and clinical data show that peripheral restricted opioids provide pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a potent dual μ-/δ-opioid receptor (MOR/DOR) full agonist, and a weak, partial agonist at the κ-opioid receptor (KOR). H...

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Detalles Bibliográficos
Autores principales: Puls, Kristina, Schmidhammer, Helmut, Wolber, Gerhard, Spetea, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840597/
https://www.ncbi.nlm.nih.gov/pubmed/35164182
http://dx.doi.org/10.3390/molecules27030919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840597/
https://www.ncbi.nlm.nih.gov/pubmed/35164182
http://dx.doi.org/10.3390/molecules27030919

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