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Tetrahydrobiopterin induces proteasome inhibitor resistance and tumor progression in multiple myeloma
Multiple myeloma (MM) still remains an incurable disease due to widespread drug resistance and high frequency of relapse. In this study, we found that tetrahydrobiopterin (BH4) promotes MM cell proliferation and tumor growth in vivo. BH4 also increases MM bortezomib (Bor) resistance in vitro and in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840911/ https://www.ncbi.nlm.nih.gov/pubmed/35150316 http://dx.doi.org/10.1007/s12032-021-01632-5 |