UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells

Resistance to 5-fluorouracil (5-FU) in chemotherapy and recurrence of colorectal tumors is a serious concern that impedes improvements to clinical outcomes. In the present study, we found that conditioned medium (CM) derived from 5-FU-resistant HCT-8/FU cells reduced 5-FU chemosensitivity in HCT-8 c...

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Detalles Bibliográficos
Autores principales: Niu, Huan, Zhao, Meng, Huang, Jing, Wang, Jing, Si, Yang, Cheng, Shan, Ding, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841122/
https://www.ncbi.nlm.nih.gov/pubmed/35151311
http://dx.doi.org/10.1186/s12964-022-00820-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841122/
https://www.ncbi.nlm.nih.gov/pubmed/35151311
http://dx.doi.org/10.1186/s12964-022-00820-8

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