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Biotin attenuates heat shock factor 4b transcriptional activity by lysine 444 biotinylation
Genetic mutations in HSF4 cause congenital cataracts. HSF4 exhibits both positive and negative regulation on the transcription of heat shock and non-heat shock proteins during lens development, and its activity is regulated by posttranslational modifications. Biotin is an essential vitamin that regu...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841385/ https://www.ncbi.nlm.nih.gov/pubmed/35198740 http://dx.doi.org/10.1016/j.bbrep.2022.101227 |