Cholesterol Induces Pyroptosis and Matrix Degradation via mSREBP1-Driven Endoplasmic Reticulum Stress in Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) is closely associated with low back pain, but its underlying mechanism remains unclear. Cholesterol is an essential nutrient in mammalian cells. Alterations in cholesterol levels lead to impairments in cell physiology, such as cell proliferation and signal tran...

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Detalles Bibliográficos
Autores principales: Yan, Jiansen, Li, Shuangxing, Zhang, Yangyang, Deng, Zhihuai, Wu, Jiajun, Huang, Zhengqi, Qin, Tianyu, Xiao, Yin, Zhou, Jie, Xu, Kang, Ye, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841752/
https://www.ncbi.nlm.nih.gov/pubmed/35174163
http://dx.doi.org/10.3389/fcell.2021.803132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841752/
https://www.ncbi.nlm.nih.gov/pubmed/35174163
http://dx.doi.org/10.3389/fcell.2021.803132

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