Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RW(d)

Signaling by bone morphogenetic proteins (BMPs) plays pivotal roles in embryogenesis, adult tissue homeostasis, and disease. Recent studies revealed that the well-established WNT agonist R-spondin 2 (RSPO2) is also a BMP receptor (BMP receptor type 1A) antagonist, with roles in early Xenopus embryog...

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Detalles Bibliográficos
Autores principales: Lee, Hyeyoon, Sun, Rui, Niehrs, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842081/
https://www.ncbi.nlm.nih.gov/pubmed/35032551
http://dx.doi.org/10.1016/j.jbc.2022.101586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842081/
https://www.ncbi.nlm.nih.gov/pubmed/35032551
http://dx.doi.org/10.1016/j.jbc.2022.101586

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