Aggregation Time Machine: A Platform for the Prediction and Optimization of Long-Term Antibody Stability Using Short-Term Kinetic Analysis

[Image: see text] Monoclonal antibodies are the fastest growing class of therapeutics. However, aggregation limits their shelf life and can lead to adverse immune responses. Assessment and optimization of the long-term antibody stability are therefore key challenges in the biologic drug development....

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Detalles Bibliográficos
Autores principales: Bunc, Marko, Hadži, San, Graf, Christian, Bončina, Matjaž, Lah, Jurij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842250/
https://www.ncbi.nlm.nih.gov/pubmed/35090111
http://dx.doi.org/10.1021/acs.jmedchem.1c02010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842250/
https://www.ncbi.nlm.nih.gov/pubmed/35090111
http://dx.doi.org/10.1021/acs.jmedchem.1c02010

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