Exploring Non-orthosteric Interactions with a Series of Potent and Selective A(3) Antagonists

[Image: see text] A library of potent and highly A(3)AR selective pyrimidine-based compounds was designed to explore non-orthosteric interactions within this receptor. Starting from a prototypical orthosteric A(3)AR antagonist (ISVY130), the structure-based design explored functionalized residues at...

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Detalles Bibliográficos
Autores principales: Miranda-Pastoriza, Darío, Bernárdez, Rodrigo, Azuaje, Jhonny, Prieto-Díaz, Rubén, Majellaro, Maria, Tamhankar, Ashish V., Koenekoop, Lucien, González, Alejandro, Gioé-Gallo, Claudia, Mallo-Abreu, Ana, Brea, José, Loza, M. Isabel, García-Rey, Aitor, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842279/
https://www.ncbi.nlm.nih.gov/pubmed/35178181
http://dx.doi.org/10.1021/acsmedchemlett.1c00598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842279/
https://www.ncbi.nlm.nih.gov/pubmed/35178181
http://dx.doi.org/10.1021/acsmedchemlett.1c00598

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