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The Roles Played by FP/EP3 Receptors During Pressure-lowering in Mouse Eyes Mediated by a Dual FP/EP3 Receptor Agonist

PURPOSE: We investigated the intraocular pressure (IOP)-lowering effect of topical sepetaprost (SPT), a dual agonist of the FP and EP3 receptors. We explored whether certain receptors mediated the hypotensive effect of SPT and outflow facility changes in C57BL/6 mice (wild-type [WT]) and FP and EP3...

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Detalles Bibliográficos
Autores principales: Yamagishi-Kimura, Reiko, Honjo, Megumi, Aihara, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842472/
https://www.ncbi.nlm.nih.gov/pubmed/35147658
http://dx.doi.org/10.1167/iovs.63.2.24