Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure–Activity Relationship Studies

[Image: see text] The trypanosome alternative oxidase (TAO), a mitochondrial enzyme involved in the respiration of the bloodstream form trypomastigotes of Trypanosoma brucei, is a validated drug target against African trypanosomes. Earlier series of TAO inhibitors having a 2,4-dihydroxy-6-methylbenz...

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Detalles Bibliográficos
Autores principales: Cisneros, David, Cueto-Díaz, Eduardo J., Medina-Gil, Tania, Chevillard, Rebecca, Bernal-Fraile, Teresa, López-Sastre, Ramón, Aldfer, Mustafa M., Ungogo, Marzuq A., Elati, Hamza A. A., Arai, Natsumi, Otani, Momoka, Matsushiro, Shun, Kojima, Chiaki, Ebiloma, Godwin U., Shiba, Tomoo, de Koning, Harry P., Dardonville, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842630/
https://www.ncbi.nlm.nih.gov/pubmed/35178188
http://dx.doi.org/10.1021/acsmedchemlett.1c00717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842630/
https://www.ncbi.nlm.nih.gov/pubmed/35178188
http://dx.doi.org/10.1021/acsmedchemlett.1c00717

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