Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

Cathepsin K (CatK) is a target for the treatment of osteoporosis, arthritis, and bone metastasis. Peptidomimetics with a cyanohydrazide warhead represent a new class of highly potent CatK inhibitors; however, their binding mechanism is unknown. We investigated two model cyanohydrazide inhibitors wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843313/
https://www.ncbi.nlm.nih.gov/pubmed/35144520
http://dx.doi.org/10.1080/14756366.2021.2024527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843313/
https://www.ncbi.nlm.nih.gov/pubmed/35144520
http://dx.doi.org/10.1080/14756366.2021.2024527

Ejemplares similares