TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis

Mutations in TGF-β–activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are currently unknown. Here, we identified an indispensable role for TAB2 in regulating myocardia...

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Detalles Bibliográficos
Autores principales: Yin, Haifeng, Guo, Xiaoyun, Chen, Yi, Zeng, Yachang, Mo, Xiaoliang, Hong, Siqi, He, Hui, Li, Jing, Steinmetz, Rachel, Liu, Qinghang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843707/
https://www.ncbi.nlm.nih.gov/pubmed/34990405
http://dx.doi.org/10.1172/JCI152297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843707/
https://www.ncbi.nlm.nih.gov/pubmed/34990405
http://dx.doi.org/10.1172/JCI152297

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