Feasibility of intracerebrally administering multiple doses of genetically modified neural stem cells to locally produce chemotherapy in glioma patients

Neural stem cells (NSCs) are tumor tropic and can be genetically modified to produce anti-cancer therapies locally in the brain. In a prior first-in-human study we demonstrated that a single dose of intracerebrally administered allogeneic NSCs, which were retrovirally transduced to express cytosine...

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Detalles Bibliográficos
Autores principales: Portnow, Jana, Badie, Behnam, Blanchard, M. Suzette, Kilpatrick, Julie, Tirughana, Revathiswari, Metz, Marianne, Mi, Shu, Tran, Vivi, Ressler, Julie, D’Apuzzo, Massimo, Aboody, Karen S., Synold, Timothy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843788/
https://www.ncbi.nlm.nih.gov/pubmed/32895489
http://dx.doi.org/10.1038/s41417-020-00219-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843788/
https://www.ncbi.nlm.nih.gov/pubmed/32895489
http://dx.doi.org/10.1038/s41417-020-00219-y

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