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Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease
Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Knock-in mice carrying a CAG repeat-expanded Htt will develop HD phenotypes. Previous studies suggested dysregulated molecular networks in a CAG length genotype- and the age-dependent manner in brain tis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843892/ https://www.ncbi.nlm.nih.gov/pubmed/35224162 http://dx.doi.org/10.1016/j.gendis.2021.05.004 |