Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Knock-in mice carrying a CAG repeat-expanded Htt will develop HD phenotypes. Previous studies suggested dysregulated molecular networks in a CAG length genotype- and the age-dependent manner in brain tis...

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Detalles Bibliográficos
Autores principales: Huang, Lulin, Fang, Li, Liu, Qian, Torshizi, Abolfazl Doostparast, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843892/
https://www.ncbi.nlm.nih.gov/pubmed/35224162
http://dx.doi.org/10.1016/j.gendis.2021.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843892/
https://www.ncbi.nlm.nih.gov/pubmed/35224162
http://dx.doi.org/10.1016/j.gendis.2021.05.004

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