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Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease

Huntington's disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Knock-in mice carrying a CAG repeat-expanded Htt will develop HD phenotypes. Previous studies suggested dysregulated molecular networks in a CAG length genotype- and the age-dependent manner in brain tis...

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Detalles Bibliográficos
Autores principales:	Huang, Lulin, Fang, Li, Liu, Qian, Torshizi, Abolfazl Doostparast, Wang, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2021
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843892/ https://www.ncbi.nlm.nih.gov/pubmed/35224162 http://dx.doi.org/10.1016/j.gendis.2021.05.004

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