Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4

Background: Management of patients with prostate cancer and bone metastatic disease remains a major clinical challenge. Loss or mutation of p53 has been identified to be involved in the tumor progression and metastasis. Nevertheless, direct evidence of a specific role for wild-type p53 (wt-p53) in b...

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Detalles Bibliográficos
Autores principales: Li, Qiji, Wang, Min, Zeng, Leli, Guo, Wei, Xu, Yuandong, Li, Chenxin, Lai, Yingrong, Ye, Liping, Peng, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844016/
https://www.ncbi.nlm.nih.gov/pubmed/35177982
http://dx.doi.org/10.3389/fphar.2021.792293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844016/
https://www.ncbi.nlm.nih.gov/pubmed/35177982
http://dx.doi.org/10.3389/fphar.2021.792293

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