Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy

Retinal neurodegeneration develops early in the course of diabetic retinopathy (DR), and our previous research showed that succinate accumulation results in retinal ganglion cells (RGCs) dysfunction in the retinas of rats with DR. Succinate can enhance lysine succinylation, but the succinylation of...

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Detalles Bibliográficos
Autores principales: Zhang, Ye, Li, Tingting, Cai, Xuan, Long, Da, Wang, Xiangning, Liu, Chang, Wu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844082/
https://www.ncbi.nlm.nih.gov/pubmed/35165261
http://dx.doi.org/10.1038/s41420-022-00861-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844082/
https://www.ncbi.nlm.nih.gov/pubmed/35165261
http://dx.doi.org/10.1038/s41420-022-00861-5

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