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Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy
Retinal neurodegeneration develops early in the course of diabetic retinopathy (DR), and our previous research showed that succinate accumulation results in retinal ganglion cells (RGCs) dysfunction in the retinas of rats with DR. Succinate can enhance lysine succinylation, but the succinylation of...
Autores principales: | Zhang, Ye, Li, Tingting, Cai, Xuan, Long, Da, Wang, Xiangning, Liu, Chang, Wu, Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844082/ https://www.ncbi.nlm.nih.gov/pubmed/35165261 http://dx.doi.org/10.1038/s41420-022-00861-5 |
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